发给老马备查:
. d+ C" k# \* K/ i, {6 n滴水察海(69304838) 15:23:23
8 ?2 j' H8 K9 ]5 L老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱
; Y( K; w. J# D# n) d5 ~$ \吉非替尼和S-1连用的依据
# Q6 d9 O) D% y# m% j& n! AGefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.7 ?; f* N D8 @' ?7 ~
是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达) R* l5 _' f, d7 u" G
这样是不是推理出,耐药后,可以用S-1和培美了?
/ O" m/ [5 E2 r结论:
u! ^- D, L" `: w如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |