发给老马备查:- m, l) Y& D& W3 S! R7 w
滴水察海(69304838) 15:23:23
8 r& T- |7 R3 m' T$ B老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱
) F% y2 P A7 K吉非替尼和S-1连用的依据
8 m0 Y, {" ^2 [ R5 M3 E* |Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.3 H4 J0 U. `% J% s! q
是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达1 d3 Y: _; F' ~" t- g
这样是不是推理出,耐药后,可以用S-1和培美了?, W* k1 u, q* y
结论:
3 A1 i# Q: r( j5 p如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |