发给老马备查:, B: P+ n# D& f4 F% k
滴水察海(69304838) 15:23:23# O5 z) f" h* T) U& r5 {( C
老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱 2 \2 k/ ?# p& M& f9 q% s& f! `+ c吉非替尼和S-1连用的依据- d* f& |3 f" L* f$ t* g/ }) |
Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.3 b* Y8 y, E4 G* ?2 f0 q2 A/ |
是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达 ( u1 ~% d& n8 D( ~$ w0 i. Z6 t+ K这样是不是推理出,耐药后,可以用S-1和培美了?2 w: h ]. Y/ l# y* f9 ]' F e5 J
结论: 4 `0 v- V3 V( ]如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。