发给老马备查:& G9 c& Q$ v9 C% p' j
滴水察海(69304838) 15:23:23
: X9 p" j9 O0 F5 v' W' }老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱6 n( x0 }; R% X
吉非替尼和S-1连用的依据& j6 D6 B5 x: e$ q
Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
& Z" y% Z) P _ X% m3 }9 d8 o2 o是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
! Z+ h; T+ {, _' G这样是不是推理出,耐药后,可以用S-1和培美了?
$ z4 M, m; @( z1 w/ U; n结论:" I& m1 x7 J4 {" D# n5 \
如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |