看见一个 Expert Review of Anticancer Therapy。你们前面用依维莫斯,血、肝肾功能还好。下一步是否考虑索拉非尼+依维莫斯。供你参考。
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Currently available feasibility data for possible combination strategies. # x5 g4 r5 f# s7 W5 w/ Z! K, r k
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Combination Feasibility according to preliminary data
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Bevacizumab + sorafenib Yes, reduced dose
I9 B, O. f" c$ @Bevacizumab + sunitinib† No
( P; F t; z# j9 b! b* x" L6 fBevacizumab + temsirolimus Yes
# p" p$ V8 u: B6 P; v, E1 e3 lBevacizumab + everolimus Yes ; f! n. Y( d0 t' V1 P9 l
Sorafenib + sunitinib ?
6 G) c# Q" y% B8 c+ MSorafenib + temsirolimus Yes, reduced dose
( g6 K' W6 T2 K5 zSorafenib + everolimus Yes, reduced dose
" H- @7 n8 j- H1 W3 F! u* d9 XSunitinib + temsirolimus† No : E( D' u4 a$ a; v s8 U9 u
Sunitinib + everolimus ?
/ o+ j! O9 ^7 PTemsirolimus + everolimus ?
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†Led to US FDA warning.: j% j: g/ k' b0 ?8 D
?: As yet unattempted combination.2 d- c( r1 _0 ]* _
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