看见一个 Expert Review of Anticancer Therapy。你们前面用依维莫斯,血、肝肾功能还好。下一步是否考虑索拉非尼+依维莫斯。供你参考。
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; [0 z1 v( g! K0 k! j! f( |* mCurrently available feasibility data for possible combination strategies.
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Combination Feasibility according to preliminary data
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) J$ Y# R# q @Bevacizumab + sorafenib Yes, reduced dose
4 L+ ?3 s, q/ M1 FBevacizumab + sunitinib† No 8 P N3 x; k: Z1 b
Bevacizumab + temsirolimus Yes 5 w- D% e- R, T8 W+ @
Bevacizumab + everolimus Yes 9 F* @) G6 n% `+ w g! r' e
Sorafenib + sunitinib ?
1 X& I+ h& g$ l. j Y: ~: x: z% _Sorafenib + temsirolimus Yes, reduced dose + E6 T* c y9 u2 Q8 A: j" m% ?
Sorafenib + everolimus Yes, reduced dose 5 h% P2 Q/ [. c% y2 e0 O
Sunitinib + temsirolimus† No
* E3 w; n- \4 }) w2 ^" wSunitinib + everolimus ?
* v) ]3 v% _. g9 @- PTemsirolimus + everolimus ?
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†Led to US FDA warning.
- P2 y9 W8 T0 x! c?: As yet unattempted combination.& n. m8 e) {0 d
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