脑部放疗，上午比下午敏感许多！0 s$ Q2 O3 w! A3 M) m z) M6 L
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Cancer 2011 Jan 15;117(2):414-20. doi: 10.1002/cncr.25423. Epub 2010 Sep 9.
2 Q3 {4 p7 ^5 T' z4 [Gamma knife radiosurgery for brain metastasis of nonsmall cell lung cancer: is there a difference in outcome between morning and afternoon treatment?+ C% A* b. w( Y) M. n4 C% Y( j. }
Rahn DA 3rd, Ray DK, Schlesinger DJ, Steiner L, Sheehan JP, O'Quigley JM, Rich T.
1 s7 A: `9 v! p1 M* }SourceDepartment of Radiation Oncology, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA.
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BACKGROUND: Circadian cell-cycle progression causes fluctuating radiosensitivity in many tissues, which could affect clinical outcomes. The purpose of this study was to determine whether outcomes of single-session gamma knife radiosurgery (GKRS) for metastatic nonsmall cell lung cancer (NSCLC) differ based on treatment time.& U. E3 ]. M' o+ @" Z: H: h
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METHODS: Fifty-eight patients received GKRS between 10:00 am and 12:30 pm and 39 patients received GKRS between 12:30 pm and 3:00 pm. The mean peripheral dose was 18.6 Gy. The mean tumor size was 7.3 cm³. Magnetic resonance imaging was used to score local control at 3 months. Cause of death (COD) was categorized as central nervous system (CNS)-related or systemic./ a! b1 i1 m* u" Y
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RESULTS: Demographic and disease characteristics of the 2 groups were similar. Local control at 3 months was achieved in 97% (35/36) of patients who underwent GKRS early in the day versus 67% (8/12) of patients who underwent GKRS later in the day (chi-square, P = .014). Early GKRS was associated with better survival (median 9.5 months) than late GKRS (median 5 months) (Kaplan-Meier log-rank test, P = .025). Factors contributing to better survival in a Cox regression model included early treatment time (P = .004) and recursive partition analysis class (P < .001). Cause of death in the early treatment group was CNS-related in 6% (3/47) of patients versus 24% (8/34) of patients in the late treatment group (chi-square test, P = .026).; |' }6 Y+ |) g' c. K. T; S- V
3 O& K( P: |1 v* |1 k! l: yCONCLUSIONS: GKRS for metastatic NSCLC had better local control, better survival, and a lower rate of CNS-related cause of death when given earlier in the day versus later in the day. These retrospective data should encourage future study in brain radiosurgery and non-CNS stereotactic body radiotherapy series.
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肺鳞癌L858R 达克替尼近三年耐药
71岁，女，无吸烟史
18年10月肺鳞癌，3X 4cm，左肺上叶切除，无转移，未化疗
22年1月
生存期显著获益，多种联合用药方案带
作者：王川
2025年欧洲肺癌大会在充满活力的巴黎隆重召开，汇聚了来自全球的专家、医
居家护理全攻略：肺癌患者的呼吸功能
讲者：隗艳审核：吴晓瑞“家”是肿瘤患者最温暖的避风港，但居家护理的每一个细节，都
妈妈肺腺9年，现在迷茫请大神路过给
病情大体介绍，患者女现69周岁，有吸烟史50年，2003年感冒憋气，CT显示肺部有片炎症，
超级好用的病历记录表格，99%的医生
各位病友大家好，自从我父亲患病以来，我每天都会详细的把他的检查结果和体感变化还
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显身卡
