脑部放疗，上午比下午敏感许多！- v/ N h# c5 V3 k8 |+ @
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Cancer 2011 Jan 15;117(2):414-20. doi: 10.1002/cncr.25423. Epub 2010 Sep 9.
8 q! C5 D; T& y6 DGamma knife radiosurgery for brain metastasis of nonsmall cell lung cancer: is there a difference in outcome between morning and afternoon treatment?
' I$ [1 O' j4 R3 z7 xRahn DA 3rd, Ray DK, Schlesinger DJ, Steiner L, Sheehan JP, O'Quigley JM, Rich T.
/ e+ S0 }8 j4 r: d4 h. XSourceDepartment of Radiation Oncology, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA.
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Abstract- P# ^2 F7 F" R" x& `
BACKGROUND: Circadian cell-cycle progression causes fluctuating radiosensitivity in many tissues, which could affect clinical outcomes. The purpose of this study was to determine whether outcomes of single-session gamma knife radiosurgery (GKRS) for metastatic nonsmall cell lung cancer (NSCLC) differ based on treatment time.
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METHODS: Fifty-eight patients received GKRS between 10:00 am and 12:30 pm and 39 patients received GKRS between 12:30 pm and 3:00 pm. The mean peripheral dose was 18.6 Gy. The mean tumor size was 7.3 cm³. Magnetic resonance imaging was used to score local control at 3 months. Cause of death (COD) was categorized as central nervous system (CNS)-related or systemic.
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RESULTS: Demographic and disease characteristics of the 2 groups were similar. Local control at 3 months was achieved in 97% (35/36) of patients who underwent GKRS early in the day versus 67% (8/12) of patients who underwent GKRS later in the day (chi-square, P = .014). Early GKRS was associated with better survival (median 9.5 months) than late GKRS (median 5 months) (Kaplan-Meier log-rank test, P = .025). Factors contributing to better survival in a Cox regression model included early treatment time (P = .004) and recursive partition analysis class (P < .001). Cause of death in the early treatment group was CNS-related in 6% (3/47) of patients versus 24% (8/34) of patients in the late treatment group (chi-square test, P = .026).1 P" u1 ]# ]9 t7 r. F! u
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CONCLUSIONS: GKRS for metastatic NSCLC had better local control, better survival, and a lower rate of CNS-related cause of death when given earlier in the day versus later in the day. These retrospective data should encourage future study in brain radiosurgery and non-CNS stereotactic body radiotherapy series.
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卡度联合安罗，谁让肿瘤缩小了
肺低分化腺，伴肉瘤样。卡度尼利单抗联合安罗替尼。两个疗程复查显示肿瘤缩小，胸膜增
父亲确诊“癌王”生命危在旦夕，医护
讲述者：吉吉整理者：pear
一年前，父亲被确诊为胰腺癌伴肝转移，那一刻，我的人生仿
收藏！一文详解肺癌MET突变检测方法
作者：闵
目前国内已上市的MET抑制剂有赛沃替尼、卡马替尼、谷美替尼、特泊替尼以及伯
肺腺癌egfr19+骨转移，这样治疗可以
病情与治疗过程概述
患者年龄58岁，男性，已戒烟30年
1. 确诊情况（2025.05.26）：患
抗癌路上的营养支持分享
2019年11月26日，家人确诊肺癌晚期，这开启了我们漫长的抗癌之路。经历了手术和四次化
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显身卡
